FISH

SMALL SUPERNUMERARY MARKER CHROMOSOMES

-  sSMC -

FOR PATIENTS

 

Japan

 

jap 2

 

Translation provided by Dr. Naoki Kakazu, Kyoto Prefectural University of Medicine, Japan

 


sSMC-karyotype

Figure 1.   46 normal chromosomes plus a small supernumerary marker chromosome = sSMC (arrow head)

 


sSMC shapes

Figure 2.   Three possible different shapes of an sSMC - schematic drawing.

 


sSMC frequ

Figure 3.   Until recently the only clinical correlations known between sSMC presence and clinical outcome based on data from 1998.
This data is still broadly used in genetic counseling.

 


sSMC-genphenscheme

Figure 4.  Potentially gene-dosage insensitive regions are labelled in green; potentially genedoasge sensitive ones are labelled in red.