FISH

SMALL SUPERNUMERARY MARKER CHROMOSOMES

-  sSMC -

BASICS - FORMATION

 

sSMC-formation

 

Overall, little is known on sSMC formation.

What we know is:
- sSMC may form from each chromosome (see this collection)
- inherited sSMC mainly derive from maternal origin {175}
- de novo sSMC often form by trisomic rescue {112-113}
- sSMC formation seems to be different according to sSMC shape (see below)

 

sSMC-formation in:
- inverted duplication shape
- ring shape
- centric minute shape
- neocentrics
- complex

 


References